Team

Principle Investigator

Name: Honghui Ma(E-mail: honghui_ma@fudan.edu.cn )

Academic qualifications                                                                          

Fudan University, Institutes of Biomedical Sciences. (Jul. 2007 ~ Jun. 2012)

Doctor of Philosophy in Biochemistry and Molecular Biology.

Fudan University, Department of Life Science (Sept. 2005 ~ Jun. 2007)

Master of Science in Genetics.

Huazhong Agricultural University, College of Life Science. (Sept. 2001 ~ Jun. 2005)

Bachelor of Science in Life Science.

Associate Professor  School of Medicine, Tongji University (Mar. 2019 ~ Mar. 2022).

Postdoc Scholar      University of Chicago, Department of Chemistry (Apr. 2014 ~ Jun. 2016).

Postdoc Scholar      Fudan University, Department of Chemistry (Jun. 2012 ~ Mar. 2014).

Present academic position

Associate Professor   Fudan University, Zhongshan Hospital affiliated to Fudan University (Jun. 2022 ~).

Previous relevant research work

(1) Ucaps-seq: a method to detect dU at single nucleotide resolution, based on cross-linking and polymerase stalling sequencing;（JACS，2022） (2) Identification of ZCCHC4, which mediates 28S rRNA m⁶A methylation and controls global translation and cell proliferation;（Nature Chemical Biology，2019） (3) Identification of METTL5, which installs rRNA m⁶A, regulates translation initiation, and promotes mouse embryonic stem cell differentiation; （EMBO reports， Cell Reports, 2020）(4) m⁶A modified RNAs promote YTHDF2 to form phase separation;(Protein Cell, 2019) (5) YTHDC2 is an m⁶A ‘reader’ protein, regulating spermatogenesis;(Cell Research) (6) Zc3h13 is a critical RNA m⁶A regulator that is part of a complex containing WTAP, Virilizer, and Hakai. Zc3h13 anchors this complex in the nucleus to facilitate m⁶A methylation and mESC pluripotency（Molecular Cell, 2018）.

Postgraduate Students

Shengqi Zhang

Zhongchi Fu

Jie Wang

Rongshan Gao

Former lab members

Liudan Jiang(PHD)

Siyun Gao(PHD)

Lei Chen(MD)

Kejing Chen(MD)